Lifetime-based multiplexed detection of viral RNA using fluorogenic aptamers

Abstract excerpt

<h4>ABSTRACT</h4> Fluorogenic aptamers (FAPs) are emerging molecular probes for viral RNA and DNA sensing. However, their use in multiplexed nucleic acid sensing has been hindered by cross-reactivity and overlapping emission spectra. Here we address these limitations by introducing a fluorescence-lifetime-based multiplexed detection strategy using variants of the DNA fluorogenic aptamer Lettuce that exhibits dis...

Topics

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• Aptamers, Nucleotide
• COVID-19
• Fluorescent Dyes
• Nucleic Acid Amplification Techniques
• Point Mutation
• Polymorphism, Single Nucleotide
• RNA, Viral
• SARS-CoV-2

Identifiers and source

Literature Corpus work

066cd87a-4a94-5708-83bb-344544eabfef

DOI

10.64898/2026.04.13.718069