Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Programmable fluorescent aptamer-based RNA switches for rapid identification of point mutations.

Nature chemistry - 1 Dec 2025

Yan Zhaoqing, Li Yudan, Eshed Amit, Wu Kaiyue, Ticktin Zachary M, Murugan Vel, Lim Efrem S, Hong Fan, Green Alexander A

Abstract excerpt

The ability to detect single nucleotide polymorphisms (SNPs) is critical for identifying genetic disorders, assessing pathogen drug resistance and preventing infection transmission. Achieving a delicate balance across sequence-specific recognition, RNA structural stability and functional efficacy based on SNP-induced changes is crucial for precise genotyping using RNA-based probes. Here we report on in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aptamers, Nucleotide
Share to COVID-19

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluorescent Dyes

Share to Nucleic Acid Amplification Techniques

Share to Point Mutation

Share to Polymorphism, Single Nucleotide

Share to RNA, Viral

Share to SARS-CoV-2

Source

Identifiers

PMID: 41272150
DOI: 10.1038/s41557-025-01995-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Programmable fluorescent aptamer-based RNA switches for rapid identification of point mutations.PMID 41272150Read ↗

Programmable Fluorescent Aptamer-Based RNA Switches for Rapid Identification of Point MutationsSemantic proximity Read ↗

Rapid and Multiplexed Nucleic Acid Detection using Programmable Aptamer-Based RNA SwitchesSemantic proximity Read ↗

Rapid and Sensitive Visual Detection of Gene Mutations via LIVE-SNP.Semantic proximity Read ↗

Catalytic amplification by transition-state molecular switches for direct and sensitive detection of SARS-CoV-2Semantic proximity Read ↗

Rapid Detection of Intact SARS-CoV-2 Using Designer DNA Nets and a Pocket-Size Smartphone-Linked FluorimeterSemantic proximity Read ↗

Competitive SNP-LAMP probes for rapid and robust single-nucleotide polymorphism detectionSemantic proximity Read ↗

Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators.Semantic proximity Read ↗

A universal probe design for colorimetric detection of single-nucleotide variation with visible readout and high specificity.Semantic proximity Read ↗

STAR-CRISPR: a one-pot ultraspecific CRISPR strategy for rapid, visualized SNV detection and genotyping in point-of-care diagnostics.Semantic proximity Read ↗

Emerging technologies for hybridization based single nucleotide polymorphism detection.Semantic proximity Read ↗

Ultrasensitive electrochemical detection of clinically relevant genetic mutations via nanoparticle surface localized amplification and machine learning.Semantic proximity Read ↗

Simultaneous identification of viruses and viral variants with programmable DNA nanobaitSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.