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Article

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.

Molecular cell - 1 Oct 2003

Goumans Marie José, Valdimarsdottir Gudrun, Itoh Susumu, Lebrin Franck, Larsson Jonas, Mummery Christine, Karlsson Stefan, ten Dijke Peter

Abstract excerpt

Transforming growth factor-beta (TGFbeta) regulates the activation state of the endothelium via two opposing type I receptor/Smad pathways. Activin receptor-like kinase-1 (ALK1) induces Smad1/5 phosphorylation, leading to an increase in endothelial cell proliferation and migration, while ALK5 pro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptor, Transforming Growth Factor-beta Type I

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Source

Identifiers

PMID: 14580334
DOI: 10.1016/s1097-2765(03)00386-1

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14580334-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.PMID 14580334Read ↗

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