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Article

Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways.

1 Sept 2011

Abstract excerpt

Genetic studies in mice and humans have revealed a pivotal function for transforming growth factor-beta (TGF-β) in vascular development and maintenance of vascular homeostasis. Mice deficient for various TGF-β signaling components develop an embryonic lethality due to vascular defects. In patients, mutations in TGF-β receptors have been linked to vascular dysplasia like Hereditary Hemorrhagic Telangiectasia (HHT)...

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PMID: 21751154
DOI: 10.14670/hh-26.1219

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