Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-β.

Experimental cell research - 15 Jan 2011

Groenendijk Bianca C W, Benus Germaine F J D, Klous Anita, Pacheco Yolanda M, Volger Oscar L, Fledderus Joost O, Ferreira Valerie, Engelse Marten A, Pannekoek Hans, ten Dijke Peter, Horrevoets Anton J G, de Vries Carlie J M

Abstract excerpt

AIMS: Activin A and transforming growth factor-β1 (TGF-β1) belong to the same family of growth and differentiation factors that modulate vascular lesion formation in distinct ways, which we wish to understand mechanistically. METHODS AND RESULTS: We investigated the expression of cell-surface receptors and activation of Smads in human vascular smooth muscle cells (SMCs) and demonstrated that activin receptor-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type I
Share to Activin Receptors, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Activins

Share to Myocytes, Smooth Muscle

Share to p38 Mitogen-Activated Protein Kinases

Share to Receptors, Growth Factor

Share to Saphenous Vein

Share to Smad2 Protein

Source

Identifiers

PMID: 20955695
DOI: 10.1016/j.yexcr.2010.10.007

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-β.PMID 20955695Read ↗

Adenoviral activin a expression prevents intimal hyperplasia in human and murine blood vessels by maintaining the contractile smooth muscle cell phenotype.Semantic proximity Read ↗

Activin A Is a Master Regulator of Phenotypic Switch in Adipose Stromal Cells Initiated by Activated Immune Cell-Secreted Interleukin-1β.Semantic proximity Read ↗

Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasiaSemantic proximity Read ↗

Transforming growth factor-betas and vascular disorders.Semantic proximity Read ↗

Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways.Semantic proximity Read ↗

TGF-β/Smad3 Stimulates Stem Cell/Developmental Gene Expression and Vascular Smooth Muscle Cell De-DifferentiationSemantic proximity Read ↗

Redistribution of the chromatin remodeler Brg1 directs smooth muscle–derived adventitial progenitor–to–myofibroblast differentiation and vascular fibrosisSemantic proximity Read ↗

Myostatin/Activin-A Signaling in the Vessel Wall and Vascular CalcificationSemantic proximity Read ↗

Gremlin promotes vascular smooth muscle cell proliferation and migration.Semantic proximity Read ↗

DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation.Semantic proximity Read ↗

Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function.Semantic proximity Read ↗

Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.