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Article

Proteomic consequences of a single gene mutation in a colorectal cancer model.

Journal of proteome research - 3 Feb 2012

Halvey Patrick J, Zhang Bing, Coffey Robert J, Liebler Daniel C, Slebos Robbert J C

Abstract excerpt

The proteomic effects of specific cancer-related mutations have not been well characterized. In colorectal cancer (CRC), a relatively small number of mutations in key signaling pathways appear to drive tumorigenesis. Mutations in adenomatous polyposis coli (APC), a negative regulator of Wnt signa...

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Identifiers

PMID: 22103262
DOI: 10.1021/pr2009109
PMCID: PMC3271737

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22103262-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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