Article

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia

2025-03-20

Abstract excerpt

<h4>Summary</h4> Accumulating evidence links pediatric cancers to prenatal transformation events, yet the influence of the developmental stage on oncogenesis remains elusive. We investigated how hematopoietic stem cell developmental stages affect leukemic transformation, disease progression, and therapy response using a novel, humanized model of NUP98::NSD1-driven pediatric acute myeloid leukemia, that is particu...

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Literature Corpus work: 66b53723-48d6-5b6d-952d-4e706706186b
DOI: 10.1101/2025.03.19.643917

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