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Article

Layered immunity and layered leukemogenicity: Developmentally restricted mechanisms of pediatric leukemia initiation.

Immunological reviews - 1 May 2023

Mendoza-Castrejon Jonny, Magee Jeffrey A

Abstract excerpt

Hematopoietic stem cells (HSCs) and multipotent progenitor cells (MPPs) arise in successive waves during ontogeny, and their properties change significantly throughout life. Ontological changes in HSCs/MPPs underlie corresponding changes in mechanisms of pediatric leukemia initiation. As HSCs and MPPs progress from fetal to neonatal, juvenile and adult stages of life, they undergo transcriptional and epigenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36588481
DOI: 10.1111/imr.13180
PMCID: PMC10301262

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