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Article

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.

Cancer discovery - 2 Mar 2026

Wang Ke, Saniei Shayan, Poddar Nikita, Martinez Isabella G, Chao Clifford, Autar Subrina, Fiore Persephone, Carcamo Saul, Sreenath Meghana, Peplinski Jack H, Ries Rhonda E, Mei Anna Huo-Chang, Rahman Noshin Azra, Mekerishvili Levan, Quijada-Álamo Miguel, Freed Grace, Zhang Mimi, Lachman Katherine, Diaz Zayna, Gonzalez Manuel M, Zhang Jing, Pham Giang, Filipescu Dan, Berisa Mirela, Balestra Tommaso, Wheeler Noelle, Reisz Julie A, D'Alessandro Angelo, Puleston Daniel J, Bernstein Emily, Chipuk Jerry E, Wunderlich Mark, Tasian Sarah K, Marcellino Bridget K, Glass Ian A, Sturgeon Christopher M, Landau Dan A, Chen Zhihong, Papapetrou Eirini P, Izzo Franco, Meshinchi Soheil, Hasson Dan, Wagenblast Elvin

Abstract excerpt

Accumulating evidence links pediatric cancers to prenatal transformation events, yet the influence of the developmental stage on oncogenesis remains elusive. We investigated how hematopoietic stem cell developmental stages affect leukemic transformation, disease progression, and therapy response using a novel, humanized model of NUP98::NSD1-driven pediatric acute myeloid leukemia that is particularly aggressive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41351880
DOI: 10.1158/2159-8290.CD-25-0556
PMCID: PMC12861042

Genes

WT1
NSD1
NUP98

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.PMID 41351880Read ↗

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