Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention

15 Oct 2019

Abstract excerpt

This review aims to provide an overview of the current knowledge of the genetic lesions driving pediatric acute myeloid leukemia (AML), emerging biological concepts, and strategies for therapeutic intervention. Hereby, we focus on lesions that preferentially or exclusively occur in pediatric patients and molecular markers of aggressive disease with often poor outcome including fusion oncogenes that involve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Histone Deacetylase Inhibitors Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31681706
DOI: 10.3389/fped.2019.00401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic InterventionPMID 31681706Read ↗

Precision medicine for high-risk gene fusions in pediatric AML: a focus on KMT2A, NUP98, and GLIS2 rearrangementsSemantic proximity Read ↗

Acute Myeloid Leukemia in Children: Emerging Paradigms in Genetics and New Approaches to TherapySemantic proximity Read ↗

Molecular Biology of Childhood LeukemiaSemantic proximity Read ↗

Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expressionSemantic proximity Read ↗

The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformationSemantic proximity Read ↗

Updates in KMT2A Gene Rearrangement in Pediatric Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Acute Myeloid Leukemias with Alterations of Lysine Methyltransferase 2A (KMT2A): Recent Therapeutic DevelopmentsSemantic proximity Read ↗

Comprehensive molecular understanding of pediatric acute myeloid leukemia.Semantic proximity Read ↗

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric LeukemiaSemantic proximity Read ↗

The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms.Semantic proximity Read ↗

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilitiesSemantic proximity Read ↗

Impact of KMT2A Rearrangement and CSPG4 Expression in Pediatric Acute Myeloid LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.