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Article

The molecular basis of leukemia.

Hematology. American Society of Hematology. Education Program - 1 Jan 2004

Gilliland D Gary, Jordan Craig T, Felix Carolyn A

Abstract excerpt

Major strides have been made in our understanding of the molecular basis of adult and pediatric leukemias. More than one hundred disease alleles have been identified and characterized in cell culture and murine models of leukemia. In some instances, molecularly targeted therapies have been developed based on these insights that are currently in clinical trials, such as small molecule inhibitors of FLT3. In...

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Topics

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Share to Antigens, CD
Share to Enzyme Inhibitors
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Receptor Protein-Tyrosine Kinases

Share to Stem Cells

Share to Translocation, Genetic

Source

Identifiers

PMID: 15561678
DOI: 10.1182/asheducation-2004.1.80

Genes

FLT3
ETV6
MAL
PTPN11
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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