Targeted mutation of zebrafish fga models human congenital afibrinogenemia.

Abstract excerpt

Mutations in the human fibrinogen genes can lead to the absence of circulating fibrinogen and cause congenital afibrinogenemia. This rare bleeding disorder is associated with a variable phenotype, which may be influenced by environment and genotype. Here, we present a zebrafish model of afibrinogenemia. We introduced targeted mutations into the zebrafish fga gene using zinc finger nuclease technology. Animals...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Afibrinogenemia
• Share to Animals, Genetically Modified
• Share to Disease Models, Animal