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Article

Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish.

Scientific reports - 4 Mar 2020

Grzegorski Steven J, Hu Zhilian, Liu Yang, Yu Xinge, Ferguson Allison C, Madarati Hasam, Friedmann Alexander P, Reyon Deepak, Kim Paul Y, Kretz Colin A, Joung J Keith, Shavit Jordan A

Abstract excerpt

The ability to prevent blood loss in response to injury is a conserved function of all vertebrates. Complete deficiency of the central clotting enzyme prothrombin has never been observed in humans and is incompatible with postnatal life in mice, thus limiting the ability to study its role in vivo. Zebrafish are able to tolerate severe hemostatic deficiencies that are lethal in mammals. We have generated a...

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Mice
Blood Coagulation and Thrombosis Mechanisms
Mutation
Protein Domains
Prothrombin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Zebrafish Biomedical Research Applications

Zebrafish Proteins

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PMID: 32132579
DOI: 10.1038/s41598-020-60840-7
PMCID: PMC7055286

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