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Article

Trans-eQTL mapping in gene sets identifies network effects of genetic variants.

Cell genomics - 10 Apr 2024

Wang Lili, Babushkin Nikita, Liu Zhonghua, Liu Xuanyao

Abstract excerpt

Nearly all trait-associated variants identified in genome-wide association studies (GWASs) are noncoding. The cis regulatory effects of these variants have been extensively characterized, but how they affect gene regulation in trans has been the subject of fewer studies because of the difficulty in detecting trans-expression quantitative loci (eQTLs). We developed trans-PCO for detecting trans effects of genetic...

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Identifiers

PMID: 38565144
DOI: 10.1016/j.xgen.2024.100538
PMCID: PMC11019359

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