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Article

The molecular basis, genetic control and pleiotropic effects of local gene co-expression.

Nature communications - 10 Aug 2021

Ribeiro Diogo M, Rubinacci Simone, Ramisch Anna, Hofmeister Robin J, Dermitzakis Emmanouil T, Delaneau Olivier

Abstract excerpt

Nearby genes are often expressed as a group. Yet, the prevalence, molecular mechanisms and genetic control of local gene co-expression are far from being understood. Here, by leveraging gene expression measurements across 49 human tissues and hundreds of individuals, we find that local gene co-expression occurs in 13% to 53% of genes per tissue. By integrating various molecular assays (e.g. ChIP-seq and Hi-C), we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34376650
DOI: 10.1038/s41467-021-25129-x
PMCID: PMC8355184

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