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Interrogation of the human cortical peptidome uncovers cell-type specific signatures of cognitive resilience against Alzheimer’s disease

2024-02-13

Abstract excerpt

Alzheimer’s disease (AD) is characterised by age-related cognitive decline. Brain accumulation of amyloid-β plaques and tau tangles is required for a neuropathological AD diagnosis, yet up to one-third of AD-pathology positive community-dwelling elderly adults experience no symptoms of cognitive decline during life. Conversely, some exhibit chronic cognitive impairment in absence of measurable neuropathology, prom...

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Literature Corpus work
667ac137-0a15-582e-be68-2bcc5ce9074d
DOI
10.21203/rs.3.rs-3891944/v1
Open publication

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Interrogation of the human cortical peptidome uncovers cell-type specific signatures of cognitive resilience against Alzheimer’s diseaseDOI 10.21203/rs.3.rs-3891944/v1
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