Back to search

Article

Transcriptome Signatures for Cognitive Resilience Among Individuals with Pathologically Confirmed Alzheimer Disease

2024-11-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Limited success to date in development of drugs that target hallmark Alzheimer disease (AD) proteins as a means to slow AD-related cognitive decline has sparked interest in approaches focused on cognitive resilience. We sought to identify transcriptome signatures among brain donors with neuropathologically confirmed AD that distinguish those with cognitive impairment from th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4c350d9d-6bb5-5b03-ad8e-86406df6378c
DOI
10.1101/2024.11.12.24317218
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Transcriptome Signatures for Cognitive Resilience Among Individuals with Pathologically Confirmed Alzheimer DiseaseDOI 10.1101/2024.11.12.24317218
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer’s diseaseSemantic proximity
Candidate Molecular Subtypes of Cognitive Resilience in Alzheimer’s Disease: A Multi-Cohort Machine Learning and Neuroimaging StudySemantic proximity
Transcriptome-wide association study of Alzheimer disease reveals many differentially expressed genes and multiple biological pathways in brain tissue from African American donorsSemantic proximity
Conserved cell-type specific signature of resilience to Alzheimer’s disease nominates role for excitatory intratelencephalic cortical neuronsSemantic proximity
Neuropathological and transcriptomic characteristics of the aged brainSemantic proximity
Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein responseSemantic proximity
Multivariate blood biomarkers capture resilience and resistance phenotypes across the Alzheimer’s disease spectrumSemantic proximity
Identification of common molecular biomarker signatures in blood and brain of Alzheimer’s diseaseSemantic proximity
MicroRNA correlates of resilience to Alzheimer’s disease identify candidate therapeutic targets for neuroprotectionSemantic proximity
A landscape of the genetic and cellular heterogeneity in Alzheimer diseaseSemantic proximity
Exploratory Single-Cell RNA Sequencing of Peripheral Blood Identifies Candidate Signatures Associated with Alzheimer’s DiseaseSemantic proximity
Association of RDoC dimensions with post-mortem brain transcriptional profiles in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.