Article

A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases and prostate cancer progression

2021-01-21

Abstract excerpt

DNA-Damage Response (DDR) proteins are crucial for maintaining the integrity of the genome by identifying and repairing errors in DNA. Variants affecting their function can have dire consequences as damaged DNA can result in cells turning cancerous. Here we compare germline and somatic variants in DDR genes, specifically looking at their locations in the corresponding three-dimensional (3D) structures, Pfam domain...

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Literature Corpus work: 666c532b-3fa7-5330-9eba-e38b90ed8578
DOI: 10.1101/2021.01.21.427605

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