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Article

Prevalence and Clinical Associations of Germline DDR Variants in Prostate Cancer: Real-World Evidence from a 122-Patient Turkish Cohort.

Genes - 26 Dec 2025

Akay Seval, Ozdemir Taha Resid, Ozer Kaya Ozge, Degirmenci Mustafa, Unal Olcun Umit

Abstract excerpt

BACKGROUND: Germline alterations in DNA damage repair (DDR) genes represent a clinically important subset of prostate cancer (PCa), but real-world data from Middle Eastern and Turkish populations remain limited. We evaluated the prevalence and clinicopathologic associations of germline DDR variants in a single-center Turkish cohort. METHODS: We retrospectively analyzed 122 men with histologically confirmed PCa...

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Identifiers

PMID: 41595443
DOI: 10.3390/genes17010023
PMCID: PMC12841403

Genes

ATM
BRCA2
CHEK2
APC
BRCA1
MSH3
NBN
RAD50

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