Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer.

doi:10.21873/invivo.11971

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Article

Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer.

In vivo (Athens, Greece) - 1 Jan 2000

Holeckova Klaudia, Baluchova Katarina, Hives Mark, Musak Ludovit, Kliment Jan, Skerenova Maria

Abstract excerpt

BACKGROUND/AIM: The aim of this study was to analyse the genetic profiles of metastatic castration-resistant prostate cancer (mCRPC) by using next generation sequencing to identify variants with pathogenic potential in nine DNA repair genes - BRCA1, BRCA2, RAD50, RAD51, RAD51C/D, ATM and ATR. MATERIALS AND METHODS: Isolated genomic DNA from peripheral blood of 50 patients with mCRPC was used for the sequencing of...

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PMID: 32606146
DOI: 10.21873/invivo.11971
PMCID: PMC7439863

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