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Germline sequencing of DNA-damage-repair genes in two hereditary prostate cancer cohorts reveals new disease risk-associated gene variants

2022-04-13

Abstract excerpt

<h4>Background</h4> Knowledge of rare, inherited variants in DNA damage repair (DDR) genes is informing clinical management in common cancers. However, defining the rare disease- associated variants in prostate cancer (PrCa) is challenging due to their low frequency. <h4>Method</h4> Here, whole-genome and -exome sequencing data from two independent, high- risk Australian and North American familial PrCa datasets w...

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Literature Corpus work
de40289f-90da-551d-8b74-8b372d7d12c3
DOI
10.1101/2022.04.11.22273677
Open publication

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Germline sequencing of DNA-damage-repair genes in two hereditary prostate cancer cohorts reveals new disease risk-associated gene variantsDOI 10.1101/2022.04.11.22273677
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