COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets.

doi:10.1093/bib/bbab220

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COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets.

Briefings in bioinformatics - 5 Nov 2021

Alsulami Ali F, Torres Pedro H M, Moghul Ismail, Arif Sheikh Mohammed, Chaplin Amanda K, Vedithi Sundeep Chaitanya, Blundell Tom L

Abstract excerpt

Mutations in hallmark genes are believed to be the main drivers of cancer progression. These mutations are reported in the Catalogue of Somatic Mutations in Cancer (COSMIC). Structural appreciation of where these mutations appear, in protein-protein interfaces, active sites or deoxyribonucleic acid (DNA) interfaces, and predicting the impacts of these mutations using a variety of computational tools are crucial...

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PMID: 34137435
DOI: 10.1093/bib/bbab220
PMCID: PMC8574963

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