Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes.

doi:10.1038/s41467-022-28945-x

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Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes.

Nature communications - 15 Mar 2022

Kohaar Indu, Zhang Xijun, Tan Shyh-Han, Nousome Darryl, Babcock Kevin, Ravindranath Lakshmi, Sukumar Gauthaman, Mcgrath-Martinez Elisa, Rosenberger John, Alba Camille, Ali Amina, Young Denise, Chen Yongmei, Cullen Jennifer, Rosner Inger L, Sesterhenn Isabell A, Dobi Albert, Chesnut Gregory, Turner Clesson, Dalgard Clifton, Wilkerson Matthew D, Pollard Harvey B, Srivastava Shiv, Petrovics Gyorgy

Abstract excerpt

In prostate cancer, emerging data highlight the role of DNA damage repair genes (DDRGs) in aggressive forms of the disease. However, DDRG mutations in African American men are not yet fully defined. Here, we profile germline mutations in all known DDRGs (N = 276) using whole genome sequences from blood DNA of a matched cohort of patients with primary prostate cancer comprising of 300 African American and 300...

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Identifiers

PMID: 35292633
DOI: 10.1038/s41467-022-28945-x
PMCID: PMC8924169

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