Article

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

2020-05-05

Abstract excerpt

<h4>SUMMARY</h4> Maternal drug exposure during pregnancy increases the risks of developmental cardiotoxicity, leading to congenital heart defects (CHDs). In this study, we used human stem cells as an in-vitro system to interrogate the mechanisms underlying drug-induced toxicity during cardiomyocyte differentiation, including anticancer tyrosine kinase inhibitor (TKI) drugs (imatinib, sunitinib, and vandetanib)....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 666369d6-0a45-5708-b7a2-d86df8dbcadc
DOI: 10.1101/2020.05.04.077024

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networksDOI 10.1101/2020.05.04.077024Read

GATA4 regulates mitochondrial biogenesis and functions during cardiac development and rescues cardiac and mitochondrial functions impaired by TKIsSemantic proximity Read

High cardiomyocyte diversity in human early prenatal heart developmentSemantic proximity Read

Vascularized Human Cardiac Organoids Reveal Endothelial–Cardiomyocyte Crosstalk and Mechanisms of Carfilzomib-Induced CardiotoxicitySemantic proximity Read

Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitmentSemantic proximity Read

Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitorsSemantic proximity Read

Heart Slice Culture System Reliably Demonstrates Clinical Drug-Related CardiotoxicitySemantic proximity Read

Thousand and one amino acid protein kinase 1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunctionSemantic proximity Read

CHD-associated enhancers shape human cardiomyocyte lineage commitmentSemantic proximity Read

Cardiotoxicity Evaluation of Tyrosine Kinase Inhibitors using Human Induced Pluripotent Stem Cell-derived Healthy and Long QT Syndrome CardiomyocytesSemantic proximity Read

Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7.Semantic proximity Read

Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic ReprogrammingSemantic proximity Read

Catecholamine-Induced Dysregulation of Cardiac Developmental Regulators in Pheochromocytoma-Associated Cardiomyopathy: A Systematic Review with Clinical Implications for Cardiac RemodelingSemantic proximity Read