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Article

Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7.

Journal of translational medicine - 25 Mar 2024

Chen Peipei, Long Junyu, Hua Tianrui, Zheng Zhifa, Xiao Ying, Chen Lianfeng, Yu Kang, Wu Wei, Zhang Shuyang

Abstract excerpt

OBJECTIVE: Long QT syndrome type 7 (Andersen-Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations. The development, differentiation and electrophysiological maturation of cardiomyocytes (CMs) changes promote the pathophysiology of Long QT syndrome type 7(LQT7). We aimed to specifically reproduce the ATS disease phenotype...

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Identifiers

PMID: 38528561
DOI: 10.1186/s12967-024-05125-7
PMCID: PMC10964537

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