Article

Vascularized Human Cardiac Organoids Reveal Endothelial–Cardiomyocyte Crosstalk and Mechanisms of Carfilzomib-Induced Cardiotoxicity

2026-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Human cardiac organoids (hCOs) provide a powerful platform for modeling heart development and disease, yet their lack of vasculature limits physiological relevance. Here, we generate vascularized human cardiac organoids (vhCOs) by assembling hCOs with blood vessel organoids, enabling the self-organized formation of unified tissues with extensive vascular networks and substantially enhanced cardi...

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Literature Corpus work: db83d84c-1486-59a7-999f-39097c952bf2
DOI: 10.64898/2026.04.14.718448

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