Article

Heart Slice Culture System Reliably Demonstrates Clinical Drug-Related Cardiotoxicity

2020-06-13

Abstract excerpt

The limited availability of human heart tissue and its complex cell composition are major limiting factors for reliable testing drug efficacy, toxicity and understanding mechanism. Recently, we developed a functional human and pig heart slice biomimetic culture system that fully preserves the viability and functionality of 300 µm heart slices for 6 days. Here, we tested the reliability of this culture system in de...

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Identifiers and source

Literature Corpus work: 388483ad-cc4b-547a-a48a-68845b248281
DOI: 10.1101/2020.06.12.148197

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