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Thousand and one amino acid protein kinase 1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunction

14 Feb 2025

Abstract excerpt

AIMS: Doxorubicin (DOX) is one of the most effective chemotherapeutic agents for various types of cancers. However, DOX often causes cardiotoxicity, which is referred to as DOX-induced cardiomyopathy (DIC). Despite extensive research, only a limited number of effective treatments are currently available. In this study, we aimed to identify a potential therapeutic target for DIC by preventing DOX-induced cell...

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Share to Cardiac electrophysiology and arrhythmias
Share to Chemotherapy-induced cardiotoxicity and mitigation
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PMID: 39964965
DOI: 10.1093/cvr/cvaf022

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