High cardiomyocyte diversity in human early prenatal heart development

Abstract excerpt

<h4>Summary</h4> Cardiomyocytes play key roles during cardiogenesis, but have poorly understood features, especially in prenatal stages. Thus, we have characterized human prenatal cardiomyocytes, 6.5– 7 weeks post-conception, in detail by integrating single-cell RNA sequencing, spatial transcriptomics, and ligand–receptor interaction information. Using a computational workflow developed to dissect cell type heter...

Topics

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• Cardiac electrophysiology and arrhythmias
• Cardiac Fibrosis and Remodeling
• Cardiomyopathy and Myosin Studies
• Congenital heart defects research
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

68f346f7-2593-57df-91d7-32c0348608fd

DOI

10.1101/2022.02.26.482029