Article

Cardiotoxicity Evaluation of Tyrosine Kinase Inhibitors using Human Induced Pluripotent Stem Cell-derived Healthy and Long QT Syndrome Cardiomyocytes

2020-05-14

Abstract excerpt

<h4>Background: </h4> Cardiotoxicity associated with tyrosine kinase inhibitors (TKIs) has been reported in several clinical trials and preclinical studies, whereas the toxicity in populations with congenital electrophysiological dysfunction remains unclarified. Methods We studied cardiotoxicities of four US Food and Drug Administration (FDA)-approved TKIs with different targets by measuring changes in cardiomyoc...

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Literature Corpus work: c170c9af-0fc7-52e4-b7b9-c8fb4787ddf4
DOI: 10.21203/rs.3.rs-27568/v1

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