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Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution

2024-05-12

Abstract excerpt

Gastric cancer (GC) is a major cause of global cancer mortality with high heterogeneity levels. To explore geospatial interactions in tumor ecosystems, we integrated 1,563 spatial transcriptomic regions-of-interest (ROIs) with 152,423 single-cell expression profiles across 130 GC samples from 70 patients. We observed pervasive expression-based intratumor heterogeneity, recapitulating tumor progression through spat...

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Literature Corpus work
ed945caa-8da4-55d4-8f4e-2ae51ca46441
DOI
10.1101/2024.05.08.593271
Open publication

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Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and EvolutionDOI 10.1101/2024.05.08.593271
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