Article
Chromosome loading of cohesin depends on conserved residues in Scc3.
Current genetics - 1 Jun 2021
Pathania Anjali, Liu Wenjie, Matityahu Avi, Irudayaraj Joseph, Onn Itay
Abstract excerpt
Cohesin is essential for sister chromatid cohesion, which ensures equal segregation of the chromatids to daughter cells. However, the molecular mechanism by which cohesin mediates this function is elusive. Scc3, one of the four core subunits of cohesin, is vital to cohesin activity. However, the mechanism by which Scc3 contributes to the activity and identity of its functional domains is not fully understood....
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