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Multi-scale integration of human brain vascular and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease risk

2025-10-13

Abstract excerpt

<h4>Summary</h4> Cerebrovascular disease frequently co-occurs with amyloid-β (Aβ) plaques and tau tangles, the pathological hallmarks of Alzheimer’s disease (AD), compounding cognitive decline. Aβ deposition is also central to cerebral amyloid angiopathy (CAA), yet peripheral biomarkers that specifically reflect CAA-related vascular pathology remain elusive. Here, we integrated proteomic, imaging, clinical, neuro...

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Literature Corpus work
cf224341-7086-5999-909b-89bd73f6c59f
DOI
10.1101/2025.10.08.25337413
Open publication

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Multi-scale integration of human brain vascular and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease riskDOI 10.1101/2025.10.08.25337413
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