Article

Proteomic profiling of Alzheimer’s disease and Vascular dementia reveals unique underlying signatures

2025-12-09

Abstract excerpt

<h4>INTRODUCTION</h4> Alzheimer’s disease (AD) and vascular dementia (VaD) account for most dementia cases. AD biomarkers remain costly and invasive, and no specific biomarkers exist for VaD. <h4>METHODS</h4> We analyzed plasma and brain proteomics in the UK Biobank (N=53,000) and ROSMAP (N=512) to identify shared and distinct proteomic signatures of AD and VaD and assess the influence of the APOE ε4 variant. <h...

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Literature Corpus work: 600f9627-2579-5976-ab15-b00c304cbd67
DOI: 10.64898/2025.12.08.25341836

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