Article

Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

2024-07-02

Abstract excerpt

<title>Abstract</title> <p>Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific mechanism-based treatment. We used Mendelian randomization to combine a unique cerebrospinal fluid (CSF) and plasma pQTL resource with the latest European-ancestry GWAS of MRI-markers of cSVD (white matter hyperintensities, perivascular spaces). We describe a new biological fingerprint of 49...

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Literature Corpus work: 16eeee33-3518-5831-ad1e-f4e6d69c16ab
DOI: 10.21203/rs.3.rs-4535534/v1

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