Article
The mutational landscape of prostate cancer.
European urology - 1 Oct 2013
Barbieri Christopher E, Bangma Chris H, Bjartell Anders, Catto James W F, Culig Zoran, Grönberg Henrik, Luo Jun, Visakorpi Tapio, Rubin Mark A
Abstract excerpt
CONTEXT: Prostate cancer (PCa) is a clinically heterogeneous disease with marked variability in patient outcomes. Molecular characterization has revealed striking mutational heterogeneity that may underlie the variable clinical course of the disease. OBJECTIVE: In this review, we discuss the common genomic alterations that form the molecular basis of PCa, their functional significance, and the potential to...
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