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Pan-cancer genomic analysis shows hemizygous <i>PTEN</i> loss tumors are associated with immune evasion and poor outcome

2022-09-17

Abstract excerpt

<h4>ABSTRACT</h4> In tumors, somatic mutations of the PTEN suppressor gene are associated with advanced disease, chemotherapy resistance, and poor survival. PTEN loss of function may occur by inactivating mutation, by deletion, either affecting one copy (hemizygous loss) leading to reduced gene expression or loss of both copies (homozygous) with expression absent. Various murine models have shown that minor red...

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Literature Corpus work
d4d1a249-10e3-5cf6-9fed-8c2983d4520e
DOI
10.1101/2022.09.16.508308
Open publication

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Pan-cancer genomic analysis shows hemizygous <i>PTEN</i> loss tumors are associated with immune evasion and poor outcomeDOI 10.1101/2022.09.16.508308
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