Article

Neurotrauma-induced vulnerability of C9orf72 ALS iPSC-motor neurons revealed by biofidelic stretch injury

2024-03-26

Abstract excerpt

<h4>ABSTRACT</h4> A hexanucleotide repeat expansion (HRE) in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, patients with the HRE exhibit a wide disparity in clinical presentation and age of symptom onset suggesting an interplay between genetic background and environmental stressors. Neurotrauma, resulting from traumatic brain or spinal...

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Literature Corpus work: 663784e2-fbbb-5970-90c0-8e80d1e92171
DOI: 10.1101/2024.03.21.586073

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