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Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice

1 Aug 2023

Abstract excerpt

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative diseases that represent ends of the spectrum of a single disease. The most common genetic cause of FTD and ALS is a hexanucleotide repeat expansion in the C9orf72 gene. Although epidemiological data suggest that traumatic brain injury (TBI) represents a risk factor for FTD and ALS, its role in exacerbating disease...

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PMID: 37527465
DOI: 10.1093/brain/awad264

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