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Article

A Model of Traumatic Brain Injury Oligomerizes Tau in Cortical Organoids and Induces Clinically Relevant Pathologies that Synergize with MAPT Mutation.

Journal of neurotrauma - 1 Nov 2025

Shiravi Shahrzad, Yufa Alexandra, Papavasileiou Paraskevi, Lotz Steven, Murphy Dylan, Bertucci Taylor, Temple Sally, Finan John D

Abstract excerpt

Traumatic brain injury (TBI) is the most important environmental risk factor for neurodegenerative disease. Tauopathy plays an important role in post-traumatic neurodegeneration. Human-induced pluripotent stem cell (hiPSC)-derived cortical organoids have exciting potential to reveal the influence of genotype on post-traumatic neurodegeneration because they permit manipulation of the genome in a human system. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40900146
DOI: 10.1177/08977151251374286
PMCID: PMC12836475

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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