Article

Picosecond Pulsed Electric Field-Induced Disaggregation of Polyglutamine Aggregates in Huntington’s Disease Neural Stem Cells

2025-05-21

Abstract excerpt

<title>Abstract</title> <p>Huntington’s disease (HD) is a neurodegenerative disorder marked by polyglutamine (PolyQ) aggregation and mitochondrial dysfunction, yet non-invasive methods to modulate these intracellular stressors remain limited. Here, we applied picosecond pulsed electric fields (psPEF)—an ultrashort bioelectronic modality—to patient-derived HD neural stem cells (NSCs) to assess changes in pathogeni...

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Literature Corpus work: 411a3a50-b757-590e-914f-eb809ba4d235
DOI: 10.21203/rs.3.rs-6486690/v1

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