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Article

Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor Neurons

20 Feb 2018

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder caused by the selective loss of the upper and lower motor neurons. Only 10% of all cases are caused by a mutation in one of the two dozen different identified genes, while the remaining 90% are likely caused by a combination of as yet unidentified genetic and environmental factors. Mutations in C9orf72, SOD1, or TDP-43 are the most...

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PMID: 29515358
DOI: 10.3389/fnins.2018.00086

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