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Injury-induced CTE-like pathology emerges in a human multicellular <i>in vitro</i> brain model and reveals mitochondrial and neurovascular regulation

2025-12-29

Abstract excerpt

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive mild head impacts, but no human-based experimental system exists to study injury-induced CTE-like pathology. Here, we establish a long-lived, human multicellular in vitro brain platform in which controlled mechanical injury induces key cellular features of CTE-like pathology. Injured cultures developed persisten...

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Literature Corpus work
2d2ecda7-9b7b-595b-8e48-9dc150fe5ffa
DOI
10.64898/2025.12.29.696879
Open publication

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Injury-induced CTE-like pathology emerges in a human multicellular <i>in vitro</i> brain model and reveals mitochondrial and neurovascular regulationDOI 10.64898/2025.12.29.696879
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