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C9ORF72-related cellular pathology in skeletal myocytes derived from ALS-patient induced pluripotent stem cells

1 Aug 2019

Abstract excerpt

ABSTRACT Amyotrophic lateral sclerosis (ALS) is a late-onset neuromuscular disease with no cure and limited treatment options. Patients experience a gradual paralysis leading to death from respiratory complications on average only 2-5 years after diagnosis. There is increasing evidence that skeletal muscle is affected early in the disease process, yet the pathological processes occurring in the skeletal muscle of...

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PMID: 31439573
DOI: 10.1242/dmm.039552

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