Article

Amplifying the heat shock response ameliorates pathology in mouse and human models of ALS and FTD.

2021-01-29

Abstract excerpt

<title>Abstract</title> <p>Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are now widely considered to be part of a disease spectrum with the identification of common pathological features and genetic causes. However, despite these advances, there remains no effective therapy for these conditions. In this study we demonstrate that mice expressing mutant valosin containing protein (VCP) deve...

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Literature Corpus work: 7ceab71b-0b2d-5f88-b68b-3d2867ebc84b
DOI: 10.21203/rs.3.rs-152813/v1

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