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Lysosome-acidifying nanoparticles rescue A30P α-synuclein induced neuronal death in cellular and <i>Drosophila</i> models of Parkinson’s disease

2024-04-25

Abstract excerpt

Parkinson’s disease (PD) is an age-related neurodegenerative disease characterized by histopathological hallmarks of Lewy bodies formed by accumulation of α-synuclein (αSyn) and progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, with clinical symptoms of motor deficits. Toxic protein accumulation of αSyn in PD is associated with autolysosomal acidification dysfunction...

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Literature Corpus work
66355076-cade-5a57-9a52-63386681e4e4
DOI
10.1101/2024.04.19.590288
Open publication

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