Article
α-Synuclein Overexpression Induces Lysosomal Dysfunction and Autophagy Impairment in Human Neuroblastoma SH-SY5Y.
Neurochemical research - 1 Nov 2020
Nascimento Ana Carolina, Erustes Adolfo G, Reckziegel Patrícia, Bincoletto Claudia, Ureshino Rodrigo P, Pereira Gustavo J S, Smaili Soraya S
Abstract excerpt
Although the etiology of Parkinson's disease (PD) is multifactorial, it has been linked to abnormal accumulation of α-synuclein (α-syn) in dopaminergic neurons, which could lead to dysfunctions on intracellular organelles, with potential neurodegeneration. Patients with familial early-onset PD frequently present mutation in the α-syn gene (SNCA), which encodes mutant α-syn forms, such as A30P and A53T, which...
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