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Article

Potential direct role of synuclein in dopamine transport and its implications for Parkinson's disease pathogenesis.

Biochemical and biophysical research communications - 3 Sept 2023

Kim Meewhi, Bezprozvanny Ilya

Abstract excerpt

Parkinson Disease (PD) is a progressive neurodegenerative disorder that is caused by dysfunction and death of dopaminergic neurons. Mutations in the gene encoding α-synuclein (ASYN) have been linked with familial PD (FPD). Despite important role of ASYN in PD pathology, its normal biological function has not been clarified, although direct action of ASYN in synaptic transmission and dopamine (DA+) release have...

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PMID: 37290280
DOI: 10.1016/j.bbrc.2023.05.110

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