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Article

Defective autophagy in a fibroin secretion-deficient silkworm mutant.

Autophagy - 1 Nov 2025

Xia Jianhua, Chen Haiqin, Wang Yuying, Hu Wenbo, Guo Kaiyu, Linghu Qingqing, Guo Pengchao, Wang Xin, Xia Qingyou, Nezis Ioannis P, Zhao Ping, Dong Zhaoming, Zhang Yan

Abstract excerpt

The silkworm Bombyx mori is an economically important insect for silk production. Its silk glands are responsible for the synthesis and secretion of silk proteins. The naked pupa (Nd), a fibroin heavy chain mutant strain of silkworm, was found to exhibit severe atrophy, degeneration of the posterior silk gland (PSG), and abnormal secretion of fibroin proteins, thereby producing little or no silk. Here, we found...

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Identifiers

PMID: 40413758
DOI: 10.1080/15548627.2025.2510843
PMCID: PMC12674476

Genes

SQSTM1
FUS
APP
BACE1
OSBPL2
PROM1
SOD1
TARDBP
UBQLN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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