Article

HAMdetector: A Bayesian regression model that integrates information to detect HLA-associated mutations

2021-07-19

Abstract excerpt

<h4>Motivation</h4> A key process in anti-viral adaptive immunity is that the Human Leukocyte Antigen system (HLA) presents epitopes as Major Histocompatibility Complex I (MHC I) protein-peptide complexes on cell surfaces and in this way alerts CD8 + cytotoxic T-Lymphocytes (CTLs). This pathway exerts strong selection pressure on viruses, favoring viral mutants that escape recognition by the HLA/CTL system, e.g....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66032f1c-6a15-53f3-af0e-f0c84c8182ca
DOI: 10.1101/2021.07.17.452375

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HAMdetector: A Bayesian regression model that integrates information to detect HLA-associated mutationsDOI 10.1101/2021.07.17.452375Read

HAMdetector: a Bayesian regression model that integrates information to detect HLA-associated mutations.Semantic proximity Read

Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope setSemantic proximity Read

HLAEquity: Examining biases in pan-allele peptide-HLA binding predictorsSemantic proximity Read

Exploration of the Roles of HLAs When Predicting Infection Status by T Cell ReceptorsSemantic proximity Read

Orthanq: transparent and uncertainty-aware haplotype quantification with application in HLA-typingSemantic proximity Read

Determining epitope specificity of T cell receptors with TCRGPSemantic proximity Read

HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication.Semantic proximity Read

Exploration of the roles of HLAs when predicting infection status by T cell receptors.Semantic proximity Read

Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed modelsSemantic proximity Read

RBM-MHC: A Semi-Supervised Machine-Learning Method for Sample-Specific Prediction of Antigen Presentation by HLA-I Alleles.Semantic proximity Read

Prioritization of SARS-CoV-2 epitopes using a pan-HLA and global population inference approachSemantic proximity Read

Integration of HLA-DR linkage disequilibrium to MHC class II predictionsSemantic proximity Read